2-amino-1,5,6,7-tetrahydropyrrolo[3,2-d]pyrimidin-4-one
4H-Pyrrolo[3,2-d]pyrimidin-4-one,2-amino-3,5,6,7-tetrahydro-
CAS: 89830-72-8
Molecular Formula: C6H8N4O
2-amino-1,5,6,7-tetrahydropyrrolo[3,2-d]pyrimidin-4-one - Names and Identifiers
2-amino-1,5,6,7-tetrahydropyrrolo[3,2-d]pyrimidin-4-one - Physico-chemical Properties
| Molecular Formula | C6H8N4O |
| Molar Mass | 152.15 |
| Density | 1.89±0.1 g/cm3(Predicted) |
| pKa | 12.78±0.20(Predicted) |
2-amino-1,5,6,7-tetrahydropyrrolo[3,2-d]pyrimidin-4-one - Introduction
4H-Pyrrolo[3,2-d]pyrimidin-4-one,2-amino-3,5,6,7-tetrahydro-, also known as 4H-Pyrrolo[3,2-d]pyrimidin-4-one,2-amino-3,5,6,7-tetrahydro-, is an organic compound with the chemical formula C8H9N3O.
The compound has the following properties:
-Appearance: White to light yellow solid
-Melting point: 132-135°C
-Solubility: Soluble in common organic solvents (such as ethanol, dimethyl sulfoxide, etc.)
The compound has a number of important uses:
-Drug research: It is an important intermediate that can be used to synthesize biologically active compounds.
-Anticancer drugs: Some studies have shown that the compound and its derivatives have anti-cancer activity and may be used in the development of anti-cancer drugs.
The method of preparing 4H-Pyrrolo[3,2-d]pyrimidin-4-one,2-amino-3,5,6,7-tetrahydro-is usually synthesized by the following steps:
1. Synthesis of pyrrole heterocycles: The appropriate acetyl amine and cyclopentanone were subjected to a ring-closing reaction under alkaline conditions to obtain 5-acetyl pyrrole.
2. Synthesis of 4-keto pyrimidine: Reaction of 5-acetylpyrrole with excess sodium cyanide to obtain 4-keto pyrimidine.
3. reduction and ring closing: in the presence of a catalyst (such as palladium), 4-ketopyrimidine is reduced to 5-position aminopyrimidine and reacted with aldehydes to form 4H-Pyrrolo[3,2-d]pyrimidin-4-one,2-amino-3,5,6,7-tetrahydro-structure.
Regarding the safety information of this compound, in view of the hazardous nature of the chemical, the following must be noted:
-This compound may be irritating and contact with skin, eyes and respiratory system should be avoided.
-Appropriate personal protective measures should be taken during use or operation, such as wearing protective gloves, goggles and protective clothing.
-Observe safety regulations and operating procedures for chemicals during storage and handling.
-When handling the compound, pay attention to the protection of the environment to avoid pollution to the environment.
The compound has the following properties:
-Appearance: White to light yellow solid
-Melting point: 132-135°C
-Solubility: Soluble in common organic solvents (such as ethanol, dimethyl sulfoxide, etc.)
The compound has a number of important uses:
-Drug research: It is an important intermediate that can be used to synthesize biologically active compounds.
-Anticancer drugs: Some studies have shown that the compound and its derivatives have anti-cancer activity and may be used in the development of anti-cancer drugs.
The method of preparing 4H-Pyrrolo[3,2-d]pyrimidin-4-one,2-amino-3,5,6,7-tetrahydro-is usually synthesized by the following steps:
1. Synthesis of pyrrole heterocycles: The appropriate acetyl amine and cyclopentanone were subjected to a ring-closing reaction under alkaline conditions to obtain 5-acetyl pyrrole.
2. Synthesis of 4-keto pyrimidine: Reaction of 5-acetylpyrrole with excess sodium cyanide to obtain 4-keto pyrimidine.
3. reduction and ring closing: in the presence of a catalyst (such as palladium), 4-ketopyrimidine is reduced to 5-position aminopyrimidine and reacted with aldehydes to form 4H-Pyrrolo[3,2-d]pyrimidin-4-one,2-amino-3,5,6,7-tetrahydro-structure.
Regarding the safety information of this compound, in view of the hazardous nature of the chemical, the following must be noted:
-This compound may be irritating and contact with skin, eyes and respiratory system should be avoided.
-Appropriate personal protective measures should be taken during use or operation, such as wearing protective gloves, goggles and protective clothing.
-Observe safety regulations and operating procedures for chemicals during storage and handling.
-When handling the compound, pay attention to the protection of the environment to avoid pollution to the environment.
Last Update：2024-04-09 21:54:55
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